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. 2019 Jan 30;19:38. doi: 10.1186/s12862-018-1341-8

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Phylogenetic maximum likelihood tree of the nAChR genes, rooted with the human 5HTR3A and 5HTR3B; the root is not displayed. The collapsed nodes represent the orthologs of the respective nAChR genes, where each color code corresponds to one nAChR gene subfamily. The invertebrate chordate (represented by amphioxus and tunicates) and protostome (represented by C. elegans and fruitfly) closest homologs are shown as non-colored nodes. The tree topology is supported by a non-parametric Ultra-Fast Bootstrap (UFBoot) analysis