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. 2019 Jan 31;7:13. doi: 10.1186/s40478-019-0660-3

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Representation of gene ontology enrichment in mice with constitutive depletion of APMAP, according to biological process (a), molecular function (b) and cellular compartment (c). Label-free quantitative proteomics (procedure described in details in the Materials and Methods section) was used to identify proteins differentially expressed in the brains of APMAP-KO mice. Significantly enriched GO terms (p-value < 0.05) were identified by comparing the list of 113 significantly altered proteins (Additional file 2: Table S1) against the whole list of 2747 detected proteins (Additional file 2: Table S1) using the 1D enrichment tool in Perseus