Fig. 5.

Analysis of cell glutamate in healthy rats. (A) Dose/response analyses of 1 × 10⁶, 2 × 10⁶, and 3 × 10⁶ HEK⁺ cells and MSCs⁺/animal on blood glutamate levels 4 h after cell administration. (B) Effect of the different treatments on blood glutamate concentration at distinct time-points in healthy animals. Data are normalized to basal glutamate levels (*p < 0.05, **p < 0.01, n = 6/group). The dashed line represents the 100% value of basal glutamate levels. Non-transfected MSCs (MSC⁻); transfected MSCs (MSC⁺); non-transfected HEK cells (HEK⁻); transfected HEK cells (HEK⁺).