Figure 7: NK cells are dispensable for the enhanced peptide vaccination effect.
(A) Mice were inoculated with WT RMA tumors or Qa-1b- tumors and vaccinated with synthetic long peptides or control long peptide. Vaccine-induced CD8 T cell responses were measured in blood using intracellular cytokine staining. Student’s t-test for statistical analysis. (B) Tumor outgrowth plots depicting RMA tumor outgrowth in individual mice in three different treatment groups. Numbers indicate fraction of tumor-free animals at day 60. (C) Survival curves of these mice (n=10 to 20 mice per group). No statistical difference was observed using log-rank analysis when NK cells were depleted.