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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: J Endocrinol. 2018 Jun 21;238(3):221–230. doi: 10.1530/JOE-18-0238

Figure 5.

Figure 5

Somatotrope LEPR null males (A) and females (B) appear to have some dysregulation of the GH secretion pattern across ages. Instead of having a continuous pattern of GH decrease, mutants actually have some increases such as at PND 5 in males (p<0.0001) and females (p<0.05) and PND 15 in females (p<0.016). The prolactin peak is significantly reduced at PND 15 in males (C) (p<0.043) and females (p<0.001) (D). Values shown are mean ± SEM, ANOVA. A,B PND 4: n=5–9, PND 5: n=14–22, PND 8: n=6–8, PND 10: n=16–23, PND 15: n=15–25. C,D PND 4: n=4–6, PND 5: n=4–6, PND 8: n=4, PND 10: n=6–8, PND 15: n=7–15.