FIG. 4.

Schematic demonstrating vascular signaling effects of Nox5. Schematic demonstrating putative mechanisms whereby activation of Nox5 leads to vascular dysfunction, contraction, and injury in cardiovascular disease. Vasoactive peptides (Ang II and ET-1), growth factors, cytokines, and hyperglycemia induce Nox5 activation and increased levels of intracellular free Ca²⁺ ([Ca²⁺]_i), which influence redox-sensitive and Ca²⁺-dependent signaling molecules associated with contraction, inflammation, growth, and endothelial function. Increased Nox5-mediated oxidative stress leads to increased protein oxidation (reversible and irreversible forms) and activation of signaling pathways that influence vascular function and structure in cardiovascular disease. PDGF, platelet-derived growth factor. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars