FIG. 6.

Nox5 and human disease. Nox5 is demonstrated to be a key regulator of calcium influx and signaling in many human cells. Nox5 regulates physiological signaling in cells from the cardiovascular, renal, and reproductive systems. Through ROS generation and oxidation, Nox5 influences signaling kinases, phosphatases, and transcription factors, resulting in contraction, inflammation, proliferation, fibrosis, and remodeling. These effects contribute to development of cardiovascular diseases, renal pathologies, and cancer. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars