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. 2019 Jan 21;30(7):945–959. doi: 10.1089/ars.2017.7327

FIG. 3.

FIG. 3.

Schematic overview of possible eGC conformations. Depending on the extracellular environment, the eGC on top of endothelial cells can exist in at least three different conformations: (i) intact, (ii) collapsed in the presence of high extracellular Na+, or (iii) shedded after treatment with TNFα or heparanase. Importantly, the different conformations also influence the nanomechanical properties and function of the eGC. TNFα, tumor necrosis factor α.