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. 2019 Jan 28;30(8):1124–1143. doi: 10.1089/ars.2018.7527

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Copyright 2019, Mary Ann Liebert, Inc., publishers

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FIG. 3. — The effects of NO fluxes on cancer cell signaling. The different levels induce cancer cell proliferation, “stemness”/metastasis, and cell death in a concentration-dependent manner. DETA/NO and SPER/NO are spontaneous NO donors. The figure shows the approximate intracellular NO flux and approximate NO release from SPER/NO when compared with the indicated concentrations of DETA/NO. cGMP, cyclic guanosine monophosphate; ERK, extracellular signal-regulated kinase; HIF, hypoxia-inducible factor; IL, interleukin; PI3K/Akt, phosphoinositide 3-kinase/protein kinase B; sGC, soluble guanylyl cyclase. Color images are available online.