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NO (<100 nM) from NOS triggers cGMP-dependent signaling events that culminate in an induction of the Warburg effect/aerobic glycolysis. At >100 nM NO flux, this signaling can bypass cGMP and independently induce similar signaling events through EGFR. EGFR, epidermal growth factor receptor; GLUT4, glucose transporter 4; TNF, tumor necrosis factor. Color images are available online.
