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Tau phosphorylation sites for the antibodies used in this study (A). These phosphorylation sites are found both in normal brain and Alzheimer disease brains. MC1 recognizes a very specific early pathological tau conformation produced by the intramolecular association between the extreme N-terminus (aa7–9) and the third microtubule repeat domain (aa313–322) of tau (B). Color image is available online at www.liebertpub.com/neu
