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. 2018 Dec 7;39:44–58. doi: 10.1016/j.ebiom.2018.11.053

Fig. 4.

Fig. 4

Fig. 4

Epigenetic profiles of CD4 αβ and CD8 αβ phenotypic subsets and the various γδ subsets. (A) Module Trait correlation matrix of the CD4 αβ and CD8 αβ differentiation stages. Beta values of gene methylation rate of genes in blue and turquoise modules in CD4 αβ and CD8 αβ. PCA analysis using genes from blue and turquoise module in CD4 and CD8 respectively. (B) Representative FACS plot of the phenotype of the individual γδ cell type from the different donors, and sorted CD4 αβ, CD8 αβ (Naïve, Memory Subsets). Heatmap clustering of genes from blue and turquoise modules from both CD4 αβ and CD8 αβ with the various γδ subsets. PCA analysis using genes of blue and turquoise module from CD4 αβ and CD8 αβ with the various γδ subsets. (C) Heatmap clustering of genes from MeSalmon module for the respective cell type. PCA analysis of genes from the MeSalmon module with the respective cell type, beta values of the genes from the MeSalmon module for the respective cell type. MSigDB Pathway Analysis using GREAT from genes of Salmon Module (FDR <0.05 and Enrichment set at 1.3-fold) (n = 3).