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. 2018 Oct 30;24:7750–7758. doi: 10.12659/MSM.911585

Figure 3.

Figure 3

Features of the miR-492 promoter region. (A) Schematic representation of p53 BS position in the miR-492 promoter region. The sequence of putative p53 response element of miR-492 was compared with the consensus p53 BS in detail. Besides, p53 BS of miR-492 was conserved among 7 primate species. The sequences were derived from the UCSC Genome Browser, and the tandem repeats of consensus p53 binding motifs in miR-492 promoter were highlighted with blue. (B) Promoter sequence 2 kb upstream and 1 kb downstream of the pre-miR-492 was visualized on the UCSC Genome Browser. Upper panel: The histone post-transcriptional modifications including H3K4me1, H3K4me3, and H3K27Ac of miR-492 promoter were presented from GM12878, H1-hESC, and HSMM cell lines, as determined by the ChIP-seq assays from ENCODE data. Lower panel: DNase cluster tracks showed DNase I hypersensitivity areas. The black or gray box indicated a higher degree of DNase I hypersensitivity. The number of cell lines hypersensitive to DNase I in the putative p53 BS was shown, as well. The locus of p53 BS was highlighted with purple. BS – binding site; ChIP – chromatin immunoprecipitation.