. 2009 Mar 1;80(3):484–492. doi: 10.1095/biolreprod.108.070839

Table 3.

Comparison of fold changes in selected testicular gene expression between TU and TU+LNG treatments.

GenBank accession no.	Description	Gene symbol	TU vs. control fold change	TU+LNG vs. control fold change
Testicular cell specific markers^a
NM_000102	Cytochrome P450, family 17, subfamily A, polypeptide 1	CYP17A1	−34.19	−50.63
AI991694	Insulin-like 3 (Leydig cell)	INSL3	−19.27	−14.38
M13981	Inhibin, alpha	INHA	−2.97	−2.63
Insulin/IGF/relaxin^a
NM_016421	Insulin-like 6	INSL6	1.57	2.10
BC005956	Relaxin 1	RLN1	1.36	2.02
Growth factor
NM_000614	Ciliary neurotrophic factor	CNTF	2.54	1.26^c
NM_004962	Growth differentiation factor 10	GDF10	−2.18	−2.08
NM_002514	Nephroblastoma overexpressed gene	NOV	−2.94	−2.85
AF523265	Fibroblast growth factor 7 (keratinocyte growth factor)	FGF7(KGF)	−1.75	−2.23
Apoptosis^a
AW135003	Apoptosis inhibitor 5	API5	−1.60	−2.08
BI826539	Ring finger protein 216	RNF216	3.94	2.62
M31159	Insulin-like growth factor binding protein 3	IGFBP3	2.06	2.70
AI335191	Death associated protein 3	DAP3	−1.74	−2.40
AI554912	BCL2-like 14 (apoptosis facilitator)	BCL2L14	2.02	2.38
NM_006718	Dleiomorphic adenoma gene-like 1	PLAGL1	−1.30	−2.18^c
BE380045	X-linked inhibitor of apoptosis	XIAP	−2.11	−1.56
AW963634	Reticulon 4	RTN4	−2.02	−1.66
Regulation of cell cycle^b
BC004207	CHK2 checkpoint homolog (S. pombe)	CHEK2	−2.72	−2.60
U20498	Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)	CDKN2D	1.38	2.05^c
AF277724	Cell division cycle 25C	CDC25C	1.16	2.01^c
NM_006718	Pleiomorphic adenoma gene-like 1	PLAGL1	−1.30	−2.18^c
AI049624	Transcription factor Dp-2 (E2F dimerization partner 2)	TFDP2	−2.82	−1.85
BG198711	Protein kinase c, alpha	PRKCA	2.83	1.96
RNA binding^a
AA865357	Heterogenous nuclear ribonucleoprotein d	HNRNPD	−1.58	−2.22^c
AA831170	Transformer-2 alpha	TRA2A	−1.36	−2.11^c
BE046511	Formin binding protein 1	FNBP1	−1.81	−2.20
AL832250	Small nuclear ribonucleoprotein polypeptide N	SNRPN	−1.75	−2.11
AA648521	Splicing factor, arginine/serine-rich 15	SFRS15	−1.47	−2.56^c
AI697540	Muscleblind-like (Drosophila)	MBNL1	−1.12	−2.26^c
BC030757	Polypyrimidine tract binding protein 2	PTBP2	−1.39	−2.44^c
AA279654	Zinc finger protein 638	ZNF638	−1.52	−2.24
BC012090	Heterogenous nuclear ribonucleoprotein A3	HNRNPA3	−2.14	−1.38
Cell junction and cytoskeleton organization^a
AA913146	Plakophilin 4	PKP4	−1.20	−2.11^c
AW151704	Par-6 partitioning defective 6 homolog beta (C. elegans)	PARD6B	−1.13	−2.02^c
NM_001942	Desmoglein 1	DSG1	2.43	2.58
NM_006035	CDC42 binding protein kinase beta (DMPK-like)	CDC42BPB	−1.49	−2.02
NM_030772	Gap junction protein, alpha 10, 59 kDa	GJA10	1.46	2.41
AI027678	Metastasis suppressor 1	MTSS1	1.17	2.12^c
AA971514	Spectrin, beta, non-erythrocytic 1	SPTBN1	−1.43	−2.06^c
BF215673	Kelch-like 4 (Drosophila)	KLHL4	−3.22	−2.86
AA481044	Formin-like 3	FMNL3	−1.93	−2.04
AA758906	Katanin p60 subunit a-like 1	KATNAL1	2.06	1.14
BF215673	Kelch-like 4 (Drosophila)	KLHL4	−3.22	−2.86
NM_001069	Tubulin, beta 2a	TUBB2A	2.03	1.62
Immune response^a
NM_006332	Interferon, gamma-inducible protein 30	IFI30	2.18	1.49
AB000221	Chemokine (C-C motif) ligand 18	CCL18	2.79	1.98^c
NM_005849	Immunoglobulin superfamily, member 6	IGSF6	2.03	1.33
AI004137	Inter-alpha (globulin) inhibitor H4	ITIH4	2.76	1.79
AF010316	Prostaglandin E synthase	PTGES	−2.41	−2.28
NM_001565	Chemokine (C-X-C motif) ligand 10	CXCL10	2.71	2.26
D90427	Alpha-2-glycoprotein 1, zinc	AZGP1	−2.44	−2.22
U19556	Serpin peptidase inhibitor, clade b (ovalbumin), member 3	SERPINB3	1.86	2.15
AV711904	Leukocyte immunoglobulin-like receptor-subfamily b	LILRB1	2.66	2.11
L25259	CD86 antigen (CD28 antigen ligand 2, B7–2 antigen)	CD86	4.27	3.26
M17565	Major histocompatibility complex, class II, DQ beta 1	HLA-DQB1	1.35	2.19

^{^a,b}

Functional annotation classifications are significantly enriched (P < 0.05) using PathwayArchitect analysis (^a) or NIH DAVID Bioinformatics Resources (^b).

^{^c}

Gene with significant difference (P < 0.05) between TU and TU+LNG treatment.