Table 1.
Bodyweight (BW) and food intake (FI) before and after the treatment
| (A) Zucker rats | ||||
|---|---|---|---|---|
| BW before (g) | BW after (g) | FI Week 3 (g) | FI week 4 (g) | |
| Control | 366.6 ± 15.7* | 384.2 ± 16.5& | 26.7 ± 1.0 | 27.7 ± 1.2 |
| Metformine | 365.3 ± 11.2* | 392.3 ± 10.2& | 27.9 ± 0.7 | 29.8 ± 0.5 |
| Melatonin | 379.7 ± 13.1* | 410.4 ± 15.7& | 29.3 ± 1.3 | 28.9 ± 1.5 |
| Met + MEL | 377.5 ± 9.0* | 407.2 ± 10.2& | 30.5 ± 1.6 | 29.8 ± 1.9 |
| (B) Sprague Dawley rats | |||||
|---|---|---|---|---|---|
| BW before (g) | BW after (g) | FI before (g) | FI Week 3 (g) | FI week 4 (g) | |
| Control | 528.6 ± 18.5 | 528.6 ± 19.1a | 14.0 ± 0.5* | 11.4 ± 0.4& d | 11.3 ± 0.2& a |
| Metformin | 531.2 ± 14.2* | 477.5 ± 16.7& ac | 14.0 ± 0.3* | 8.6 ± 0.7& bc | 10.4 ± 0.6£ a |
| Melatonin | 528.1 ± 20.1 | 534.33 ± 25.4a | 14.1 ± 0.8* | 12.5 ± 1.0& a | 11.8 ± 0.8*a |
| Met + MEL | 523.6 ± 17.1* | 463.8 ± 10.5& bc | 13.4 ± 0.3* | 6.6 ± 0.4& b | 8.6 ± 0.2& b |
For a given treatment group (horizonal lines), means with different symbols (*, &, or £) are significantly different for a given parameter (ie, bodyweight or food intake) between steps (P < 0.001). For a given parameter at a given step (columns), means with different letters (a, b, c, or d) are significantly different between treatment groups (P < 0.001). Data are means ± SEM.