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. Author manuscript; available in PMC: 2019 Mar 26.
Published in final edited form as: Compr Physiol. 2018 Mar 26;8(2):555–583. doi: 10.1002/cphy.c170027

Figure 3.

Figure 3

Simplified cellular model of the role of apical Na+/H+ exchange in transepithelial sodium, glucose, and water absorption in small intestinal epithelial cells. SGLT1, sodium/glucose cotransporter 1, SLC5A1; GLUT2, glucose transporter 2, SLC2A2; DRA, downregulated in adenoma, SLC26A3; PAT1, putative anion transporter 1, SLC26A6; CFTR, cystic fibrosis transmembrane conductance regulator, Kir7.1, potassium inwardly rectifying channel, subfamily J, member 13, KCNJ13; ClC-2, chloride channel protein 2, CLCN2. For detailed reviews about the physiology and pathophysiology of intestinal electrolyte transport and Na+/H+ exchange in particular, see Fuster and Alexander (93), He and Yun (115), Zachos et al. (339), and Gurney et al. (109)