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. Author manuscript; available in PMC: 2019 Mar 26.
Published in final edited form as: Compr Physiol. 2018 Mar 26;8(2):555–583. doi: 10.1002/cphy.c170027

Figure 4.

Figure 4

Colonic epithelial Na+/H+ exchange in relation to other electrolyte fluxes and short-chain fatty acid absorption and metabolism. NHE1, NHE2, NHE3, and NHE8, Na+/H+ exchangers; SLC9A, SLC9A2, SLC9A3, and SLC9A8, respectively; DRA, downregulated in adenoma, SLC26A3; CFTR, cystic fibrosis transmembrane conductance regulator; AE1, anion exchanger 1, SLC4A4; MCT1, monocarboxylate transporter 1, SLC16A1. Apical SCFA−/Cl− exchange indicated with question mark depicts described transport modality without identified transport protein/gene responsible. SCFA-H, protonated short-chain fatty acids; SCFA-, ionized forms of short-chain fatty acids. For additional sources, the reader is referred to reviews listed in Figure 3, and Binder (22) and Kunzelmann and Mall (160).