Figure 1.

Adaptive optics scanning light ophthalmoscopy imaging in CNGA3-associated ACHM. At 2° eccentricity: (A) confocal image, with red dots marking the dark cones. Cones are surrounded by waveguiding rods. (B) Split-detection image over the exact same region with overlying red dots showing the cones marked in panel A, which colocalize with cone inner segments, surrounded by rods. Foveal center: (C) confocal image at the foveal center, where the dark cones are not visible because no rods are present to delineate the dark spaces. (D) Split-detection image over the exact same region, with visible and quantifiable cone inner segments. All images are from the same retinal montage. Scale bar: 20 μm.