Table 1. Selected T. cruzi vaccine candidates.
| Vaccine type | Formulation | Reduction in parasitemia | Reference |
|---|---|---|---|
| Recombinant proteins | Tc24 and TSA-1 with Th1 adjuvant | Yes | [21, 25, 26] |
| Recombinant proteins | TS with diverse adjuvants | Yes | [27] |
| Recombinant protein | Tc80 oligopeptidase with CpG adjuvant | Yes | [28] |
| Recombinant proteins/DNA vaccine | TcG2/TcG4 DNA prime/protein boost with cytokine adjuvants | Yes | [29] |
| Recombinant adenovirus | Adenovirus expressing ASP-2 and TS | Yes | [23] |
| Live attenuated parasites | Specific gene deletion causing attenuation | Yes | [30] |
Abbreviations: ASP-2, Amastigote surface protein; Tc24, T. cruzi 24 kDa antigen; Tc80, T. cruzi 80 kDa antigen; TcG2/TcG4, T. cruzi G2/G4 antigens; Th1, T helper 1; TS, trans-sialidase; TSA-1, Trypomastigote surface antigen.