Fig 5. Matrix of whole-genome effective interactions between 539 partitions.

Effective interactions between partitions, calculated according to Eq 12 (see Materials and Methods) and plotted on a logarithmic color scale. Massive interactions are formed by chromosomes 14–20, 22, and 1 (clusters of dark pixels), whereas chromosomes 4, 5, 9, 21, and X are not involved in many interactions (lighter pixels). To construct a representation of inter-chromosomal interactions via partitions of comparable sizes, we used partitions of the third level of hierarchy in chromosomes 1–12 and X, second level in chromosomes 13–21, and first level in chromosome 22.