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. 2018 Aug 13;33(1):1098–1109. doi: 10.1096/fj.201701586R

Figure 2.

Figure 2

Male mice lacking HDAC6 develop hepatic steatosis after exposure to LDP. A–C) Liver histology samples obtained at the end of the experiment reported in Fig. 1A. Top and middle row: hematoxylin and eosin staining. Lower row: Oil Red O lipid staining. LDP-treated HDAC6−/y mice developed mild to moderate hepatic steatosis. At low-power magnification (top row), macrovesicular steatosis is notable. At high-power magnification, microvesicular steatosis is observed within hepatocytes (arrowheads, middle row). Scale bars: 100 µm (upper panels), 1000 µm (middle and lower panels). Representative (A) and quantitative (B, C) data are shown. D) Serum insulin measurements collected at the end of the experiment. Data shown as means ± sem. *P < 0.05 (Kruskal-Wallis test with Dunn’s multiple comparisons test).