Figure 8.

MCK-Lpin1^Δ115 and MCK-Lpin1^−/− mice have altered exercise endurance and increased exercise plasma creatine kinase when unfed. A, C) Exercise endurance time to exhaustion in 3–4-mo-old and 1-yr-old MCK-Lpin1^Δ115, respectively. B, D) Exercise endurance time to exhaustion in 3–4-mo-old and 1-yr-old MCK-Lpin1^−/−, respectively. Additionally, plasma creatine kinase is elevated in MCK-Lpin1^−/− mice compared with their WT controls. Sedentary indicates that plasma creatine kinase was measured under fed and rested conditions; 3-h post-ex indicates that plasma creatine kinase was measured after being unfed overnight, and 3 h after the time to exhaustion in an acute bout of treadmill exercise. Data are shown as means ± sem. *P < 0.05 (Student’s t test) for differences in MCK-Lpin1^Δ115 or MCK-Lpin1^−/− compared with respective WT littermate mice; n = 7–9.