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. 2018 Jun 22;33(1):181–194. doi: 10.1096/fj.201800459R

Figure 4.

Figure 4

Muscle Igf1 deletion in young adult male mice leads to increased body weight and minimal changes in muscle mass. A) Schematic of experimental design using deletion of Igf1 in young adult males (aMID). B, C) IGF-I content of quadriceps (n = 5–7) (B) and serum (n = 5) (C) of male aMID and control was measured by ELISA. aMID mice had significantly lower quadriceps and serum IGF-I content than their age-matched controls. D) Body weight was significantly higher in 16-wk-old aMID mice than in control mice (n = 7/group). E) Normalized muscle mass was not affected by Igf1 deletion, and all comparisons had minimal effect size. Data are represented as means ± sem. *P < 0.05, **P < 0.01 (aMID vs. control), by Student’s t test, with effect size presented as Cohen’s d.