Skip to main content
. 2018 Jun 22;33(1):181–194. doi: 10.1096/fj.201800459R

Figure 5.

Figure 5

Muscle Igf1 deletion leads to diminished muscle function and reduced fatigue resistance. Isometric tetanic force measurements of isolated EDL (A) and soleus (B) from 16-wk-old control and MID male mice reveal significantly lower specific force in bMID EDL, but no differences in force production between MID and control soleus (n = 5–10). Fatigue tests of EDL (C) and soleus (D) caused a more rapid loss of relative force in both muscles from aMID mice (n = 5–11), as shown by the 42 and 40% reduction, respectively, in the time to reach 50% of initial force. Data are represented as means ± sem. Statistical analysis was performed by 1-way ANOVA, followed by a Tukey multiple-comparison test. Nonlinear fits of fatigue tests assumed 1-phase decay. Multiple Student’s t tests were performed between aMID, bMID, and control at the different time points during the fatigue run. **P < 0.01 (bMID vs. control in the same condition), ****P < 0.001 (aMID vs. control).