Figure 2.

Effects of dietary epicatechin on physical activity and SkM pathology. Twenty-month-old male C57BL/6 mice were treated with EC (0.25% in drinking water) or control (OC) for 9 mo (37 wk). A–D) Physical activity metrics [distance traveled (A), ambulatory episodes (B), ambulatory time (C), ambulatory count (D)] were tested by using a computer-controlled activity monitoring system at 20, 22, 24, and 28 mo of age (n = 12/group). E) SkM tissue (quadriceps) specimens were pathologically analyzed after H&E and PAS staining. Original magnification, ×400: Arrow indicates central nucleation; arrowhead indicates degenerating fiber. ^#P < 0.05 OC vs. YC; *P < 0.05 EC vs. OC. n = 12.