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. 2018 Aug 10;33(1):965–977. doi: 10.1096/fj.201800554RR

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This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Dietary epicatechin reversed age-related changes in gene expressions and pathways of quadriceps muscles in aged mice. The mRNA sequencing results show that a clear separation between YC and OC, and epicatechin intake significantly shifted back to YC (A) according to the principal component analysis. Nearly all genes of 4 pathways—matrisome [25 genes (B)], PPAR [8 genes (C)], lipids and lipoprotein [17 genes (D)], and NAD [5 genes (E)]—showed decreased expression during aging, but expression of all genes were significantly reversed by epicatechin intake. ^#P < 0.05 EC vs. YC; *P < 0.05 EC vs. OC (n = 8/group).