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. 2018 Jul 19;33(1):711–721. doi: 10.1096/fj.201800602R

Figure 6.

Figure 6

AICAR rescues cardiac decline from TAC in SRC-2–CKO animals. A, B) Echocardiography measurements for the percentage of fractional shortening (%FS; A) and left ventricular interior diameter in diastole (LVIDd; B); n = 5–18 (see Table 1 for n at each time point.) WT + saline data after TAC have been previously published (28). C) qPCR for atrial natriuretic factor in RNA in gene Nppa isolated from the left ventricle regions of WT and SRC-2–CKO hearts at 4 wk after TAC surgery. Expression is normalized to GAPDH; n = 5–6. D) Tei index calculated from cardiac Doppler measurements at 4 wk after TAC; n = 10 (WT + saline), n = 8 (WT + AICAR), and n = 7 (CKO + saline and CKO + AICAR) Results are presented as the means ± sem analyzed by 2-way ANOVA with multiple comparisons and with a Tukey’s post hoc analysis. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001.