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. 2018 Jun 29;33(1):204–218. doi: 10.1096/fj.201800826R

Figure 1.

Figure 1

The combination of HFD and HSD, but not HFD and HFrD, leads to β-cell insulin resistance. A) Body weight of mice fed a control diet, HFHSD, or HFHFrD (n = 5–11). B) Glucose tolerance obtained by IPGTT and depicted as AUC of the IPGTT in mice fed a control diet, HFHSD, or HFHFrD (n = 5–10). C) Whole-body insulin tolerance obtained by IPITT and depicted as AUC of the IPITT in mice fed a control diet, HFHSD, or HFHFrD (n = 5–9). D) Liver insulin tolerance obtained by IPPTT and depicted as AUC of the IPPTT in mice fed a control diet, HFHSD, or HFHFrD (n = 5–8). E) Relative β-cell insulin resistance measured using the β-cell insulin resistance biosensor (βIRB) in islets transplanted into the ACE in mice fed a control diet, HFHSD, or HFHFrD (n = 4–14). *P < 0.05,**P < 0.01, ***P < 0.001. Data are expressed as means ± sem. See also Supplemental Fig. S1.