Figure 7.

Longitudinal functional analysis of Mks6^Δ retinas. A–C) Conditional loss of Mks6 results in visual deficits. Overlaid representative scotopic and photopic ERG traces at the lowest and highest flash intensities (0.1 and 25 cd ⋅ s/m²) from dark-adapted Mks6^FL control (black) and Mks6^Δ mutant (red) animals. Scotopic and photopic ERGs were recorded in the same cohort of animals. A) One week P.I. does not display a phenotype. B, C) Five week (B) and 12 wk (C) P.I. both display visual deficits. D) Rod and cone response summary data averaged across Mks6^FL (black circles) and Mks6^Δ (red circles) animals are shown over a period of 12 wk. E) Scotopic a-wave summary data averaged across Mks6^FL (black circles) and Mks6^Δ (red circles) at 1 wk and 12 wk P.I. a-wave amplitude was measured as baseline to trough, whereas b-wave amplitude was measured baseline to peak at each flash intensity. Mks6^Δ a- and b-wave amplitudes were significantly decreased at 12 wk of age compared with Mks6^FL controls. Repeated measures of ANOVA were performed, means ± sd, n = 3 per group.