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Interactions of the core of the TIMP1 reactive site with the active site of collagenase 1 (MMP-1). The image was generated from the structure of the N-TIMP1/MMP-1 complex, pdb 2JOT (107) using the University of California, San Francisco (UCSF) chimera package (106). Residues of N-TIMP1 are labeled in red, and those of MMP-1 in black. Atom colors are as follows: C, silver; N, blue; O, red; S, yellow; and Zn, pink.
