TABLE 3.
Rates of evolutionary change for TIMP1 and TIMP2 in mammals calculated from amino acid sequence differences between human, other eutherian, marsupial, and one monotreme TIMP
| Parameter | Cana | Mus | Rat | Bos | Dun | Tas | Plat | Mean (rate) | Vert (rate) |
|---|---|---|---|---|---|---|---|---|---|
| H. sapiens to divergence time (Mya)b | 96 | 90 | 90 | 96 | 159 | 159 | 177 | ||
| TIMP1 | |||||||||
| % Change | 20.7 | 26.3 | 28.5 | 13.0 | 52.2 | 51.1 | 48.1 | ||
| Correctedc | 23.2 | 30.5 | 33.5 | 13.9 | 73.8 | 67.1 | 73.2 | ||
| Rated | 24.1 | 33.9 | 37.2 | 14.5 | 46.4 | 42.2 | 41.4 | 34.2 | 22.7 |
| TIMP2 | |||||||||
| % Change | 3.1 | 1.5 | 1.5 | 5.2 | 7.7 | 8.8 | NA | ||
| Corrected | 3.1 | 1.5 | 1.5 | 5.3 | 8.0 | 9.2 | |||
| Rated | 3.2 | 1.7 | 1.7 | 5.5 | 5.0 | 5.8 | 3.8 | 5.1 |
NA, not available. aSpecies: Bos, Bos taurus; Can, Canis familiaris; Dun (dunnart), Sminthopsis crassicaudata; Mus, Mus musculus, Rat, Ratus norvegicus, Plat (platypus) Ornithorhynchus anatinus; Tas (Tasmanian devil) Sarcophilus harrisii. bDivergence times were obtained from the TimeTree website: www.timetree.org (44). cPoisson correction for multiple substitutions at the same site –Ln(1-p), where p is the fractional change. dSubstitutions per 100 residues change per 100 million years of divergence.