Table 1.

FWER from four multiple comparison procedures MCP_B, MCP_P, MCP_S and $MC{P}_S^{MV}$

				Continuous outcome				Binary outcome
m00	m10	m01	m11	MCPB	MCPP	MCPS	$MC{P}_S^{MV}$	MCPB	MCPP	MCPS	$MC{P}_S^{MV}$
110	0	0	0	0.00	0.03	0.01	0.01	0.00	0.01	0.00	0.00
95	15	0	0	0.00	0.04	0.01	0.01	0.00	0.03	0.01	0.01
70	40	0	0	0.01	0.07	0.03	0.03	0.02	0.06	0.02	0.02
95	0	15	0	0.00	0.04	0.02	0.03	0.00	0.07	0.01	0.02
80	15	15	0	0.01	0.05	0.04	0.04	0.01	0.08	0.05	0.08
55	40	15	0	0.02	0.04	0.05	0.04	0.01	0.02	0.03	0.02
1010	0	0	0	0.00	0.02	0.00	0.00	0.00	0.02	0.00	0.00
995	15	0	0	0.00	0.04	0.00	0.01	0.00	0.05	0.01	0.01
700	310	0	0	0.00	0.06	0.01	0.01	0.00	0.04	0.00	0.00
995	0	15	0	0.00	0.04	0.00	0.01	0.00	0.05	0.00	0.00
980	15	15	0	0.00	0.03	0.01	0.01	0.00	0.03	0.01	0.03
685	310	15	0	0.02	0.05	0.04	0.05	0.00	0.07	0.00	0.06

Note: The first four columns show the number (m₀₀) of biomarkers associated with neither exposure nor outcome, the number (m₁₀) associated with only the exposure, the number (m₀₁) associated with only the outcome and the number (m₁₁) associated with both exposure and outcome. The remaining columns show the FWER, defined to be the mean proportion of simulations with at least one biomarker identified as a mediator, when $\alpha =0.05$. Details of the simulation can be found in Section 2.