Micro-CT analysis of bone formation due to the implantation with the scaffolds of different pore sizes (100, 250, 400 μm) 4, 8, and 12 weeks post surgery. a) 3D reconstructed micro-CT images of the tissue samples with calvarial bone defects with or without implantation with scaffolds of different pore sizes (bone tissue, grey; residual scaffold materials, yellow). b) Morphometric analysis of bone mineral density (BMD) and bone volume (BV). All data are expressed as the mean ± standard deviation (SD), and * indicates statistically significant difference with p < 0.05 (n = 4).