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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Nat Rev Genet. 2019 Jan;20(1):39–50. doi: 10.1038/s41576-018-0063-5

Fig. 4 ∣. Nuclear lamina-mediated genome organization.

Fig. 4 ∣

The nuclear lamina underlies the inner nuclear membrane (INM) and is connected to the genome through lamin-associated proteins. Lamin-associated domains (LADs) are large, gene-poor regions of heterochromatin that interact with the lamina at the nuclear periphery and are often enriched in repressive histone modifications, such as histone 3 lysine 9 methylation (H3K9me) and histone 3 lysine 27 acetylation (H3K27ac) (red). Histone modifiers and transcriptional regulators have been suggested to cooperate with INM proteins to maintain LADs. A-type lamins, in association with lamina-associated polypeptide 2α (LAP2α), can also interact with regions of euchromatin within the nucleus that are enriched in active histone modifications, including H3K4me and H3K9ac (green). BAF, barrier-to-autointegration factor; H3K9me2, H3K9 dimethylation; H3K9me3, H3K9 trimethylation; HP1, heterochromatin protein 1; LBR, lamin B receptor.