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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Nat Rev Genet. 2019 Jan;20(1):39–50. doi: 10.1038/s41576-018-0063-5

Fig. 5 ∣. Nuclear decline over cellular ageing.

Fig. 5 ∣

a ∣ Proliferating cells eventually exit the cell cycle and senesce as cellular ageing progresses. These senescent cells exhibit a disrupted lamina meshwork and altered chromatin organization. b ∣ Postmitotic cells do not divide and must maintain their function over cellular ageing. However, the identification of proteins that undergo limited turnover in non-dividing cells suggests that these proteins accumulate damage that leads to nuclear decline. Two prominent characteristics of long-lived postmitotic cells are the loss of nucleocytoplasmic compartmentalization and increased transcriptional noise.