| gFOBT | FIT |
|---|---|
| Sensitivity for CRC: 50.0% (15.0% to 85.0%) | Sensitivity for CRC (cut-off of 10 μg/g): 92.1% (95% CI = 86.9% to 95.3%) |
| Specificity for CRC: 88.0% (85.0% to 89.0%) | Specificity for CRC (cut-off of 10 ug/g): 85.8% (95% CI = 78.3% to 91.0%) |
| Qualitative | Quantitative: cut-offs can be adjusted, altering test sensitivity and specificity |
| 2 samples from 3 stools | 1 sample from 1 stool |
| Dietary interference: false positives (meat), false negatives (vitamin C) | No dietary interference |
| False positives from upper GI bleeding | No false positives from upper GI bleeding |
CRC = colorectal cancer. FIT = faecal immunochemical test. gFOBT = guaiac-based faecal occult blood test. GI = gastrointestinal.