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editorial
. 2019 Feb;69(679):60–61. doi: 10.3399/bjgp19X700853
gFOBT FIT
Sensitivity for CRC: 50.0% (15.0% to 85.0%) Sensitivity for CRC (cut-off of 10 μg/g):
92.1% (95% CI = 86.9% to 95.3%)
Specificity for CRC: 88.0% (85.0% to 89.0%) Specificity for CRC (cut-off of 10 ug/g):
85.8% (95% CI = 78.3% to 91.0%)
Qualitative Quantitative: cut-offs can be adjusted, altering test sensitivity and specificity
2 samples from 3 stools 1 sample from 1 stool
Dietary interference: false positives (meat), false negatives (vitamin C) No dietary interference
False positives from upper GI bleeding No false positives from upper GI bleeding

CRC = colorectal cancer. FIT = faecal immunochemical test. gFOBT = guaiac-based faecal occult blood test. GI = gastrointestinal.