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. 2019 Jan 22;129(2):863–874. doi: 10.1172/JCI123980

Figure 5. Retinal thinning in affected visually impaired animals is due to cone photoreceptor loss.

Figure 5

Comparing the topographical thickness of retinal layers in the parafoveal region (A, control blue, affected red) shows thinning of the retina. The reduced thickness is secondary to thinning in the outer nuclear layer and photoreceptor outer segments. The other retinal layers are of similar thickness to unaffected controls. The thickness of retinal layers was measured by semiautomated segmentation of SD-OCT horizontal scans through the foveal center (B, unaffected control left, affected right). Inner plexiform layer (IPL), inner nuclear layer (INL), outer nuclear layer (ONL + inner segments), photoreceptor outer segments (POS). n = 4 for each group.