Appendix Table 5.
Dysphagia, pneumonia, and stricture regressed on surgical treatments in multivariable models.
| Dysphagia No. pts (%), OR (95% CI) |
Stricture No. pts (%), OR (95% CI) |
Pneumonia No. pts (%), OR (95% CI) |
Aspiration
pneumonia No. pts (%), OR (95% CI) |
|||||
|---|---|---|---|---|---|---|---|---|
| Treatment Modality | ||||||||
| Surgery + adjuvant therapy | 2,074/4,430 (46.8) | 2.77 (2.44–3.15) | 480/4,430 (10.8) | 1.97 (1.56–2.49) | 1,067/4,430 (24.1) | 1.36 (1.17–1.58) | 364/4,430 (8.2) | 1.73 (1.36–2.20) |
| Surgery alone | 1,109/4,147 (26.7) | -Ref- | 193/4,147 (4.7) | -Ref- | 800/4,147 (19.3) | -Ref- | 208/4,147 (5.0) | -Ref- |
| Race/Ethnicity | ||||||||
| Other | 148/389 (38.1) | 1.20 (0.69–2.09) | 15/389 (3.9) | 1.30 (0.85–2.00) | 92/389(23.7) | 1.05 (0.77–1.43) | 33/389 (8.5) | 1.22 (0.77–1.93) |
| Hispanic | 170/399 (42.6) | 1.58 (0.93–2.68) | 39/399 (9.8) | 0.69 (0.43–1.11) | 90/399 (22.6) | 0.86 (0.62–1.18) | 27/399 (6.8) | 0.93 (0.56–1.53) |
| Black | 181/390 (46.4) | 1.24 (0.75–2.07) | 52/390 (13.3) | 0.99 (0.70–1.42) | 96/390 (24.6) | 1.10 (0.81–1.50) | 28/390 (7.2) | 0.99 (0.60–1.64) |
| Caucasian | 2,684/7,399 (36.3) | -Ref- | 567/7,399 (7.7) | -Ref- | 1,589/7,399 (21.5) | -Ref- | 484/7,399 (6.5) | -Ref- |
| Age quartiles | ||||||||
| >79 | 914/2,705 (33.8) | 1.01 (0.85–1.20) | 152/2,705 (5.6) | 0.73 (0.54–0.99) | 673/2,705 (24.9) | 1.59 (1.30–1.95) | 200/2,705 (7.4) | 1.45 (1.05–1.99) |
| 74–79 | 742/1,985 (37.4) | 1.06 (0.88–1.27) | 151/1,985 (7.6) | 0.90 (0.67–1.22) | 419/1,985 (21.1) | 1.23 (0.99–1.52) | 130/1,985 (6.6) | 1.25 (0.89–1.74) |
| 69–74 | 933/2,367 (39.4) | 1.01 (0.85–1.20) | 216/2,367 (9.1) | 0.95 (0.72–1.25) | 473/2,367 (19.9) | 1.13 (0.93–1.39) | 137/2,367 (5.8) | 1.04 (0.75–1.44) |
| <69 | 594/1,520 (39.1) | -Ref- | 154/1,520 (10.1) | -Ref- | 302/1,520 (19.9) | -Ref- | 105/1,520 (6.9) | -Ref- |
| Disease sub-site | ||||||||
| Nasopharynx | 27/53 (50.9) | 0.94 (0.35–2.51) | NR | 2.55 (0.72–9.12) | 99/307 (32.3) | 1.71 (0.62–4.71) | NR | 3.23 (1.03–10.15) |
| Oropharynx | 237/397 (59.7) | 1.19 (0.95–1.50) | NR | 1.76 (1.28–2.43) | 269/911 (29.5) | 0.88 (0.68–1.15) | NR | 0.81 (0.54–1.21) |
| Larynx | 597/1,217 (49.1) | 0.82 (0.69–0.98) | NR | 2.42 (1.88–3.12) | 1,361/4,304 (31.6) | 1.36 (1.12–1.66) | NR | 0.93 (0.68–1.27) |
| Oral cavity | 1,849/4,726 (39.1) | -Ref- | NR | -Ref- | 522/1,645 (31.7) | -Ref- | NR | -Ref- |
| Missing | 473 | 387 | ||||||
| Sex | ||||||||
| Female | 1,283/3,676 (34.9) | 0.70 (0.54–0.91) | 254/3,676 (6.9) | 0.82 (0.67–1.01) | 709/3,676 (19.3) | 0.85 (0.75–0.98) | 191/3,676 (5.2) | 0.68 (0.54–0.85) |
| Male | 1,900/4,901 (38.8) | -Ref- | 419/4,901 (8.6) | -Ref- | 1,158/4,901 (23.6) | -Ref- | 381/4,901 (7.8) | -Ref- |
| Comorbidity | ||||||||
| 2 | 531/1,281 (41.5) | 1.34 (1.14–1.58) | 113/1,281 (8.8) | 1.11 (0.83–1.47) | 433/1,281 (33.8) | 2.28 (1.92–2.70) | 132/1,281 (10.3) | 1.84 (1.42–2.40) |
| 1 | 816/2,067 (39.5) | 1.26 (1.09–1.44) | 175/2,067 (8.5) | 1.20 (0.95–1.52) | 520/2,067 (25.2) | 1.54 (1.32–1.79) | 152/2,067 (7.4) | 1.26 (0.98–1.63) |
| 0 | 1,836/5,229 (35.1) | -Ref- | 385/5,229 (7.4) | -Ref- | 914/5,229 (17.5) | -Ref- | 288/5,229 (5.5) | -Ref- |
| SEER stage | ||||||||
| Distant | 295/660 (44.7) | 2.13 (1.65–2.75) | 50/660 (7.6) | 1.82 (1.35–2.47) | 186/660 (28.2) | 2.00 (1.57–2.54) | 53/660 (8.0) | 1.69 (1.16–2.46) |
| Regional | 1,353/2,869 (47.2) | 1.24 (0.78–1.96) | 268/2,869 (9.3) | 1.54 (1.21–1.96) | 688/2,869 (24.0) | 1.42 (1.22–1.65) | 238/2,869 (8.3) | 1.61 (1.27–2.05) |
| In situ/Localized | 1,075/4,018 (26.8) | -Ref- | 205/4,018 (5.1) | -Ref- | 714/4,018 (17.8) | -Ref- | 188/4,018 (4.7) | -Ref- |
| Unstaged/missing | 460 | 82 | 279 | 93 | ||||
| Total | 3,183/8,577 (37.1) | 673/8,577 (7.9) | 1,867/8,577 (21.8) | 572/8,577 (6.7) | ||||
NR, numbers of patients not reported for cells in which n≤11 observations contributed to the estimate.