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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Glia. 2018 Dec 11;67(3):452–466. doi: 10.1002/glia.23555

FIGURE 9.

FIGURE 9

GRPs significantly reduced the macrophage response both within the lesion site and in the intact caudal spinal cord surrounding PhMNs. There were almost no ED1+ cells in the intact C2 spinal cord in laminectomy-only control rats (a). There was a substantial increase in ED1+ cell counts by 1 day posthemisection (b), and these counts progressively increased out to 10 days (c) and 35 days (d) post-SCI (quantification in e). Compared with fibroblasts (f), GRPs (g) significantly reduced the number of ED1+ cells (h) and the intensity of ED1 immunostaining (i) in the lesion site at 5 weeks post-SCI. Compared with fibroblasts (j–j”), GRPs reduced numbers of ED1+ cells in the ipsilateral C3–C5 ventral horn (k–k”) at 5 weeks posthemisection (l). Scale bar: 50 μm