Table 4.
Complex | Dark | Vis lighta | Red lightc | ||
---|---|---|---|---|---|
EC50 / μM | EC50 / μM | PIb | EC50 / μM | PId | |
3 | 67.0±0.91 | 0.27±0.01 | 248 | 58.9±0.69 | 1 |
5 | > 300 | 0.69±0.01 | > 435 | 136±5.73 | > 2 |
16 hours drug-to-light interval followed by 100 J·cm−2 broadband visible light irradiation,
PI = phototherapeutic index (ratio of dark EC50 to visible-light EC50),
16 hours drug-to-light interval followed by 100 J·cm−2 light irradiation with 625-nm LEDs,
PI = phototherapeutic index (ratio of dark EC50 to red-light EC50).