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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Biomaterials. 2018 Jun 26;198:27–36. doi: 10.1016/j.biomaterials.2018.06.034

Fig. 2. Designer immune tissues facilitate isotype class switching.

Fig. 2.

A) Formalin fixed paraffin embedded splenic tissue from immunized WT and Ezh2fl/fl Cγ1-cre (EZH2 KO) mouse stained for GC marker peanut agglutinin (PNA, brown) and hematoxylin (blue). One representative picture of three spleens analyzed is shown. B) The relative EZH2 MFI in EZH2+GL7+ CD19 + B cells derived in immune tissues using Ezh2fl/fl Cγ1-cre mouse derived naïve B cells and normalized to WT samples. Experiments were done with n = 6, presented as mean ± standard error (scatter plot only) with statistical significance indicated by p < 0.05 (***P < 0.0001, **P < 0.001). Statistical tests were performed using 1-way ANOVA with Tukey’s correction. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)