Figure 8. Alterations of von Willebrand factor over time in thrombocytopenic and control dogs.
Similar increases in vWF:Ag in both groups of dogs likely reflect vWF’s induction as an acute phase reactant secondary to biopsies (P<0.0001 for change in vWF:Ag over time). However, vWF may also play a role as a marker of thrombocytopenic endothelial damage as demonstrated by its correlation with large vacuole score. Plasma vWF:Ag concentration is reported as percent compared to a normal canine standard (median, range).