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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Dev Biol. 2018 Jul 31;444(Suppl 1):S170–S180. doi: 10.1016/j.ydbio.2018.07.026

Figure 3. Axial-specific features of the neural crest gene regulatory network (GRN).

Figure 3.

(A) Simplified diagram of the pan-neural crest gene regulatory network, which does not account for differences among subpopulations, and the cranial-specific subcircuit contributing to ectomesenchymal differentiation. Neural plate border genes (HH5–6) regulate the expression of neural crest specification and migration genes (HH8–10) (B-C) Enrichment of neural crest genes in the cranial vs. trunk populations suggests the presence of axial-specific circuits. NPB: Neural Plate Border; NC Sp: Neural Crest Specification; NC. Mig: Neural Crest Migration