Table 2.
Dose Attenuation by Organ Dysfunctions.
| Cytotoxic agents | Cause of reduction | 100% | 75% | 50% | 25% | 0% |
|---|---|---|---|---|---|---|
| CY | Liver damage | T.Bil<3.0 mg/dL and AST ≤179 IU/L | T.Bil 3.1-4.9 mg/dL or AST>179 IU/L | - | - | T.Bil ≥5 mg/dL |
| CCR | CCR ≥10 mL/min | - | CCR<10 mL/min | - | - | |
| DOX | Liver damage | T.Bil<1.2 mg/dL and AST and ALT<2XULNR | AST or ALT 2-3X of ULNR | T.Bil 1.2-2.9 mg/dL or AST of ALT>3XULNR | T.Bil 3.0-4.9 mg/dL | T.Bil ≥5 mg/dL |
| CCR | CCR ≥10 mL/min | CCR<10 mL/min | - | - | ||
| VCR | Liver damage | T.Bil<1.5 mg/dL and AST<60 IU/L | - | T.Bil 1.5-3.0 mg/dL or AST 60-179 IU/L | T.Bil 3.1-4.9 mg/dL | T.Bil ≥5 mg/dL or AST ≥180 IU/L |
| CCR | any | - | - | - | - |
ALT: alanine aminotransferase, AST: aspartate aminotransferase, CCR: creatinine clearance, CY: cyclophosphamide, LDH: lactate dehydrogenase, DOX: doxorubicin, PHY: physicians’ decision group, PS: performance status, R-IPI: Revised International Prognostic Index, T.Bil: total bilirubin, ULNR: upper limit of normal range, UNI: unified dose-attenuation group, VCR: vincristine