Table 5.
Univariate and Multivariate Analyses of EFS and OS.
| EFS | OS | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| univariate | multivariate | univariate | multivariate | ||||||||
| HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | ||||
| Age (≥70) | 1.48 (0.91-2.4) | 0.12 | ND | - | 1.74 (0.85-3.55) | 0.131 | ND | - | |||
| Albumin (≥3.5 g/dL) |
0.68 (0.42-1.11) | 0.121 | ND | - | 0.2746 (0.13-0.59) | 0.001 | 0.44 (0.19-0.99) | 0.047 | |||
| Treatment group (UNI) | 0.52 (0.37-0.86) | 0.011 | 0.50 (0.30-0.83) | 0.0072 | 0.59 (0.28-1.25) | 0.167 | 0.50 (0.24-10.8) | 0.079 | |||
| CCI (≥3) | 2.29 (1.36-3.89) | 0.0019 | 1.77 (1.03-3.03) | 0.0039 | 3.77 (1.62-8.75) | 0.002 | 2.22 (0.92-5.35) | 0.076 | |||
| LDH (normal) | 0.5 (0.3-0.83) | 0.0079 | ND | - | 0.32 (0.14-0.7) | 0.0048 | ND | - | |||
| IPI (≥3) | 2.93 (1.68-5.1) | 0.00015 | 2.75 (1.55-4.86) | 0.0005 | 5.54 (2.13-14.43) | 0.00045 | 3.72 (1.38-10.0) | 0.010 | |||
| PS (≥2) | 3.01 (1.78-5.1) | 0.00004 | ND | - | 3.43 (1.62-7.28) | 0.0013 | ND | - | |||
CCI: Charlson Comorbidity Index, CI: confidence interval, EFS: event-free survival, HR: hazard ratio, IPI: International Prognostic Index, LDH: lactate dehydrogenase, ND: not done, OS: overall survival, PS: performance status, UNI: unified dose-attenuation group