Fig. 3.

Protein subset predictive for CCTA-defined absence of coronary atherosclerosis. Importance plot (left panel) illustrates the relative importance of all 34 plasma proteins predictive for CCTA-defined absence of coronary atherosclerosis. The spiderplot (right panel) depicts the 11 most important proteins in our machine learning model that differentiate between the presence (red) and absence of coronary atherosclerosis (green). The axis of the spiderplot represents the standardized mean protein levels (scaled zero-mean unit-variance). Standaridized mean levels of LEP and UMOD were higher in the absence of CAD group compared to the presence of CAD group. Conversely GDF-15, CCL24, CHIT1, REN, PLA2G7, MMP12, OPG, TNFRSF9, and MB were lower in patients with absence of CAD. Abbrevations of protein names are defined in Supplementary Table 1.