Figure 8.

Anaplastic lymphoma kinase (ALK)-positive(⁺) lymphoma cells are sensitive to CDK6 inhibitor. NPM-ALK⁺ ALCL SU-DHL1 (A-D), COST (E-H) and KARPAS-299 (KARPAS) (I-L) cells were treated or not (H2O) with palbociclib, an CDK4/6 inhibitor. Cell count at three different time points (0, 1, 2 days) (A, E and I), cell cycle distribution (B, F and J), caspase 3/7 activity (C, G and K) and cell proliferation rate (D, H and L) were measured. Data represent means±SEM (bars) from 3 independent experiments. *P<0.05; **P<0.001; ***P<0.0001; ns: not significant; unpaired two-tailed Student’s t-test with Welch’s correction. Data represent means±Standard Error of Mean (bars) from 3 independent experiments, *P<0.05; **P<0.001; unpaired two-tailed Student’s t-test with Welch’s correction.