Table 3.

Bioenergetic measurements (mean ± SEM) on oxygen consumption rate (pg. O₂/10,000 cells) in peripheral monocytes isolated from healthy controls and patients with porphyria.

Group	Basal	ATP linked	Proton leak	Maximal	Reserve	Non-mitochondrial
Healthy controls (N = 18)	2.53 ± 0.17	2.01 ± 0.15	0.55 ± 0.05	6.39 ± 0.59	3.83 ± 0.50	1.32 ± 0.08
All porphyria (N = 22)	2.19 ± 0.24	1.60 ± 0.17	0.38 ± 0.06	4.94 ± 0.91	3.26 ± 0.64	1.34 ± 0.39
Porphyria cutanea tarda (N = 12)	2.04 ± 0.36	1.44 ± 0.25	0.43 ± 0.08	4.52 ± 1.19	2.89 ± 0.86	1.19 ± 0.26
Acute hepatic porphyria (N = 7)	2.05 ± 0.18	1.79 ± 0.21	0.25 ± 0.007	5.28 ± 0.39	3.22 ± 0.52	0.64 ± 0.02
Active porphyria (N = 8)	1.92 ± 0.47	1.66 ± 0.43	0.26 ± 0.08	4.44 ± 1.38	2.54 ± 1.00	0.60 ± 0.55
Student's t-Test P*	0.19	0.015	0.14	0.06	0.25	0.90
Student's t-Test P**	0.39	0.014	0.025	0.0002	0.009	0.34
Wilcoxon Rank Sum P*	0.15	0.013	0.09	0.018	0.06	0.035
Wilcoxon Rank Sum P**	0.25	0.015	0.018	0.002	0.012	0.27

*Healthy controls vs. all porphyria and **Healthy controls vs. active porphyria.