TABLE 2.
Mutations in the putative promoter and pncA gene reported in this studya
| Genotype | Reported frequency | PZA susceptibility profile | % |
|---|---|---|---|
| Promoter (A-11G) | 1 | Resistant | 0.5 |
| D49N | 1 | Resistant | 0.5 |
| D8E | 2 | Resistant | 1.0 |
| F81S | 2 | Susceptible | 1.0 |
| H51R | 10 | Resistant | 5.2 |
| H57L | 1 | Resistant | 0.5 |
| H57R | 1 | Resistant | 0.5 |
| H71R | 2 | Resistant | 1.0 |
| I6S | 2 | Resistant | 1.0 |
| K48T | 9 | Susceptible | 4.7 |
| P62S | 1 | Susceptible | 0.5 |
| Q10P | 2 | Resistant | 1.0 |
| Q10R | 13 | Resistant | 6.7 |
| Δ375–389 | 1 | Resistant | 0.5 |
| Δ456–466 | 3 | Resistant | 1.6 |
| Wild type | 142 | Susceptible | 73.6 |
a
Specific mutations are reported along with the strain’s corresponding PZA susceptibility profile according to the Tuberculosis Drug Resistance Mutation Database.