FIG 2.

Histological examination of lungs harvested from mice treated with placebo, APX001, or posaconazole. Mice were infected and treated as in Fig. 1B. Harvested, fixed lungs were stained with GMS prior to microscopic examination. Notice the focal fungal pneumonia (indicated by the abscesses in the placebo mice with elongated intact hyphae) and tissue edema versus a smaller abscess in the 78-mg/kg APX001 dose image with fragmented fungal hyphae and less tissue edema (arrows). Treatment with higher doses of APX001 or posaconazole resulted in normal lung architecture with no signs of fungal pneumonia.